I run a pair of 2 stage compressors with the pressure switches slightly offset. 90% of the time only one compressor runs, if I am using a lot of air the second compressor will kick in and help. I have them tied into one feeder line that enters 2 stages of oil/water canister filters before going into a hankison refrigerated dryer. I am currently regulating pressure at the inlet of the dryer, about 120 psi. Out of the dryer my air splits off in different directions. I go 3/4" to my main feeders for shop tool air and I have a 1/2" that goes to my booth. Outside of my booth I have a sharpe 3 stage cleaner/dryer with desiccant. I follow the desiccant with a motorguard sub micronic filter, then I go through the wall into the booth with Milton V style fittings and a 3/8" hose.
I'm happy with my setup except I need to add one more regulator, then I can move my current regulator to the post dryer position along with another. (one for my booth feeder and one for my shop air lines.) I want to cut my shop air back to 100 psi but I'd like to leave my booth feeder at around 125.
I guess I'd only use enough flex to get from your tank to your hard lines.