All SPI 2K urethane activators contain isocyanate, which means most primers (except epoxy) all but one clear (intercoat clear is 1K), and I believe bedliner activator also has isocyanate. Basecoat when mixed per SPI's recommendation will also contain a small amount of isocyanate.
Proper body and respiratory protection is required for all use of SPI products regardless of their isocyanate content, all auto paint products can cause health problems or death if absorbed in sufficient quantities.