The best would be to use the epoxy as a sealer but using the 2K as a sealer will work also. One of the benefits with epoxy is the recoat window being longer one draw back would be if you get a fisheye because you applied it a little heavy where the 2K is a little more user friendly in that reguard when going straight to paint.
I should have asked, are you starting the job or going to paint after the sealer? If starting the job epoxy is the best if bondo work needs done, you have up to 7 days before scuffing is recommended.