Great question!
Of course the answer really depends on the product and brand.
Some clears do not like being reduced and that can cause die-back.
SPI does not care about reducer as long as a good grade, low grades can and will kill the clear.
Some clears can cause their own die-back if flash times are not long enough because of the low amount of solids. Not the SPI.
SPI clears can die-back from the following:
Abuse of polar accelerator.
Using a crap reducer.
Baking to hot or to long.
Leaving the booth fan running to long.
Now the above should give you a general idea to why and the differences in clears.
Now the truth, of all the calls I get for die-back, it is 99% of the time, from the base coat solvents.