I've been using High Five #N893 nitrile gloves. Not indestructible but hold up pretty decent when cleaning the gun and can still feel the tools for mechanic stuff. I keep plenty in stock so when they tear I replace before my hands get a mess.
The best gloves I've used for paint and solvent were called "thicksters", don't remember where they came from. Those gloves were fine for painting/cleaning but too thick for anything else. The latex doctor gloves are usually weak and solvent wrecks them right away.
There was also some cream stuff that you coated your hands with prior to working. Kind of worked but if you touched any water it turned slippery and it dried out my skin pretty bad.
The Zep Co. made a hand cleaner called "Painters Partner" that worked pretty good to lift paint off but that dries the skin also.
I've had my share of paint, filler, grease etc. and stained cracked skin over the years, tried a lot of things, and found that a decent gauge of nitrile, powder free gloves works the best all around for me.
The icocyanates in the hardeners we use should not contact your skin.